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pentobarbital will lessen the extent or result of prednisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will lessen the level or effect of darifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital improves toxicity of methoxyflurane by escalating